Protein tertiary structure recognition using optimized Hamiltonians with local interactions.
basic_science · Level V
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- Record sourced from PubMed, PMID 1409599.
- Also identified by PMC identifier 50058.
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Abstract
Protein folding codes embodying local interactions including surface and secondary structure propensities and residue-residue contacts are optimized for a set of training proteins by using spin-glass theory. A screening method based on these codes correctly matches the structure of a set of test proteins with proteins of similar topology with 100% accuracy, even with limited sequence similarity between the test proteins and the structural homologs and the absence of any structurally similar proteins in the training set.
Medical subject headings
- Protein Structure, Tertiary