Autoantibodies against a serine tRNA-protein complex implicated in cotranslational selenocysteine insertion.
basic_science · Level V
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- Record sourced from PubMed, PMID 1409691.
- Also identified by PMC identifier 50208.
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Abstract
We describe an autoantibody specificity present in a subgroup of patients with a severe form of autoimmune chronic active hepatitis. These antibodies precipitate a 90-nucleotide RNA from human whole cell extracts and recognize a 48-kDa polypeptide in immunoblotting assays. The RNA is a UGA suppressor serine tRNA that carries selenocysteine (tRNA[Ser]Sec)), as shown by sequence analysis. The protein does not appear to be seryl-tRNA synthetase; rather, it is an excellent candidate for a factor involved in cotranslational selenocysteine incorporation in human cells.
Medical subject headings
- Autoantibodies
- Autoantigens
- Autoimmune Diseases
- Hepatitis, Chronic
- RNA, Transfer, Ser
- Ribonucleoproteins
- Selenocysteine