Circulating lymphocyte subsets in second- and third-trimester fetuses: comparison with newborns and adults.
cross_sectional · Level IV
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Abstract
Our objective was to compare the relative sizes of circulating lymphocyte subsets in fetuses, newborns, and adults. Two-color flow cytometric analysis of lymphocyte cell surface markers was performed on blood from 64 fetuses, 22 newborns, and 67 normal adults. All three groups had similar percentages of CD3+ total T cells, CD4+ helper T cells, CD8+ cytotoxic/suppressor T cells, and CD20+ B cells. Compared with adults, fetuses and newborns had markedly reduced percentages of CD57+ natural killer T cells and consistently increased percentages of CD5+CD20+ B cells. Most fetal and cord T and B lymphocytes expressed the activation marker CD38. Similarities and age-dependent differences exist among fetal, newborn, and adult circulating lymphocyte subsets. Lymphocyte marker analysis may prove useful in the detection of fetal infection and other complications of gestation.
Medical subject headings
- Blood Cells
- Fetal Blood
- Lymphocyte Subsets