Accumulation of fluoxetine and norfluoxetine in human brain during therapeutic administration.
other · Level V
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Abstract
In vivo 19fluorine nuclear magnetic resonance spectroscopy was used to measure the brain concentration of fluoxetine and norfluoxetine in five patients with obsessive-compulsive disorder and three with major depression. The mean brain:plasma ratio of the parent drug plus the metabolite was significantly elevated to 2.6 (SD = 1.0) (95% confidence interval = 1.9-3.3). This accumulation may have implications for understanding both the therapeutic and the toxic effects of fluoxetine.
Medical subject headings
- Brain
- Depressive Disorder
- Fluoxetine
- Obsessive-Compulsive Disorder