Systemic lupus erythematosus induced by isoniazid.
case_report · Level V
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- Record sourced from PubMed, PMID 1417144.
- Also identified by PMC identifier 1004845.
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Abstract
The case is described of a 73 year old man who presented with a lupus-like syndrome related to treatment with isoniazid and had IgG antinuclear antibodies against the nucleo-histone complex (H2A-H2B)-DNA. After a short course of treatment with prednisone and discontinuation of isoniazid the patient's lupus symptoms resolved and a gradual decrease in antibodies to (H2A-H2B)-DNA occurred. This case suggests that isoniazid is capable of inducing an autoantibody specificity associated with drug related lupus.
Medical subject headings
- Isoniazid
- Lupus Erythematosus, Systemic