Porcine model for studying the passage of non-depolarizing neuromuscular blockers through the blood-brain barrier.
basic_science · Level V
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Abstract
A method has been developed for blood-brain barrier disruption to provide reproducible access to the cerebrospinal fluid of the cerebello-medullary cistern. The technique was used successfully to investigate transfer of pancuronium to the cerebral CSF compartment in pigs. After osmotic disruption of the blood-brain barrier, pancuronium concentrations increased significantly in the cerebrospinal fluid.
Medical subject headings
- Blood-Brain Barrier
- Models, Biological
- Neuromuscular Nondepolarizing Agents