Lesions of basal ganglia due to disulfiram neurotoxicity.
case_report · Level V
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- Record sourced from PubMed, PMID 1431956.
- Also identified by PMC identifier 1015193.
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Abstract
Three cases of disulfiram induced Parkinsonism and frontal lobe-like syndrome associated with bilateral lesions of the lentiform nuclei on CT scan are reported. Symptoms developed either after an acute high dose of disulfiram (one case) or after several days to weeks of disulfiram treatment (two cases) and persisted over several years in two patients. These observations suggest that basal ganglia are one of the major targets of disulfiram neurotoxicity. The mechanisms of the lesions of basal ganglia may involve carbon disulfide toxicity.
Medical subject headings
- Alcoholism
- Basal Ganglia Diseases
- Disulfiram
- Drug Overdose
- Neurologic Examination