Association of methotrexate, rheumatoid arthritis and lymphoma: report of 2 cases and literature review.
case_report · Level V
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Abstract
We describe 2 Caucasian men with rheumatoid arthritis (RA) who developed non-Hodgkin's lymphoma of identical histological type during treatment with low dose oral weekly methotrexate (MTX). Both patients had longstanding RA and had been treated with MTX for over 2 years at time of tumor diagnosis; neither had secondary Sjögren's syndrome. The oncogenic potential of MTX and RA arthritis is reviewed.
Medical subject headings
- Arthritis, Rheumatoid
- Lymphoma, Non-Hodgkin
- Methotrexate