Thrombotic thrombocytopenic purpura in systemic lupus erythematosus and antiphospholipid antibodies: effective treatment with plasma exchange and immunosuppression.
case_report · Level V
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Abstract
We describe 2 patients with systemic lupus erythematosus (SLE) with neurological complications and thrombocytopenia, who, upon further investigation, were found to have thrombotic thrombocytopenic purpura. While neither patient responded to treatment with corticosteroids, both responded to plasma exchange and intravenous cyclophosphamide. This highlights the need to carefully consider this diagnosis in patients with SLE presenting with neurological complications and thrombocytopenia.
Medical subject headings
- Antibodies, Antiphospholipid
- Antiphospholipid Syndrome
- Immunosuppressive Agents
- Lupus Erythematosus, Systemic
- Plasma Exchange
- Purpura, Thrombotic Thrombocytopenic