Crystal structure of staphylococcal enterotoxin B, a superantigen.
basic_science · Level V
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Abstract
The three-dimensional structure of staphylococcal enterotoxin B, which is both a toxin and a super-antigen, has been determined to a resolution of 2.5 A. The unusual main-chain fold containing two domains may represent a general motif adopted by all staphylococcal enterotoxins. The T-cell receptor binding site encompasses a shallow cavity formed by both domains. The MHCII molecule binds to an adjacent site. Another cavity with possible biological activity was also identified.
Medical subject headings
- Enterotoxins
- Protein Conformation
- Protein Structure, Secondary