Immobilization of DNA for scanning probe microscopy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 1438201.
- Also identified by PMC identifier 50291.
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Abstract
Reproducible scanning tunneling microscope and atomic force microscope images of entire molecules of uncoated plasmid DNA chemically bound to surfaces are presented. The chemically mediated immobilization of DNA to surfaces and subsequent scanning tunneling microscope imaging of DNA molecules demonstrate that the problem of molecular instability to forces exerted by the probe tip, inherent with scanning probe microscopes, can be prevented.
Medical subject headings
- DNA, Bacterial
- DNA, Circular
- Plasmids