CSF hypocretin levels in Guillain-Barré syndrome and other inflammatory neuropathies.
cross_sectional · Level IV
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Abstract
CSF hypocretin-1 was measured in 28 Guillain-Barré syndrome (GBS), 12 Miller-Fisher syndrome, 12 chronic inflammatory demyelinating polyneuropathy (CIDP), and 48 control subjects. Seven GBS subjects had undetectably low hypocretin-1 levels (<100 pg/mL). Hypocretin-1 levels were moderately reduced in an additional 11 GBS, 5 Miller-Fisher syndrome, and 1 CIDP subject. Low levels in GBS occurred early in the disease and were associated with upper CNS level abnormalities.
Medical subject headings
- Carrier Proteins
- Guillain-Barre Syndrome
- Intracellular Signaling Peptides and Proteins
- Miller Fisher Syndrome
- Neuropeptides
- Polyradiculoneuropathy, Chronic Inflammatory Demyelinating