The secret life of histones.
basic_science · Level V
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- Record sourced from PubMed, PMID 14505563.
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Abstract
Recent evidence reveals an unexpected role for the linker histone H1.2 in DNA damage-induced apoptosis. DNA double strand breaks induce translocation of nuclear H1.2 to the cytoplasm, where it promotes release of cytochrome c from mitochondria by activating the Bcl-2 family protein, Bak.
Medical subject headings
- Apoptosis
- Cell Nucleus
- DNA Damage
- Eukaryotic Cells
- Histones