Naproxen as an alternative to aspirin for the treatment of arthritis of rheumatic fever: a randomized trial.
rct · Level II
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Abstract
We performed a prospective, randomized, open-label equivalence study comparing the use of naproxen to aspirin in 33 patients with rheumatic fever. The mean time until resolution of arthritis was 2.9+/-2.9 days in both groups. Liver enzyme elevations were more frequent in the aspirin group (P=.002). We conclude that naproxen is as effective, is easier to use, and is safer than aspirin in the treatment of the arthritis of rheumatic fever.
Medical subject headings
- Anti-Inflammatory Agents, Non-Steroidal
- Aspirin
- Naproxen
- Rheumatic Fever