Estimation of the spatio-temporal correlations of biological electrical sources from their magnetic fields.

Abstract

Quasi-static electromagnetic systems, such as those found in biological systems, produce electric and magnetic fields whose temporal and spatial correlations reflect the source correlations in a straightforward manner. These fields can be noninvasively measured, providing information about the coherence properties of the source, which may directly represent ordered physiological processes of the organism. The description "biocoherence" will be adopted here to refer to the manifestation of the coherence in the magnetic measurements of these sources due solely to physiological processes. In this paper a general formulation linking the spatial and temporal coherence of measurable magnetic fields with the corresponding spatial and temporal coherence of the inaccessible current sources is derived in the quasi-static model. A method for reconstructing the spatial and temporal coherence of the source distribution is then presented. Such coherence maps would be useful descriptors of physiological processes occurring over time and space, and would represent more information than an image of the current sources frozen in time, or even a temporal sequence of such images.