Hepatoprotection via the IL-6/Stat3 pathway.
expert_opinion · Level V
Where this comes from
- Record sourced from PubMed, PMID 14523032.
- Also identified by PMC identifier 198534.
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Abstract
Stat3 is a vital transcription factor that is activated downstream of the gp130 receptor, primarily via IL-6 signaling in adult liver. A new study demonstrates that Stat3 provides hepatoprotection against Fas-mediated apoptotic liver damage by two mechanisms: direct inactivation of caspases and reduction of reactive oxygen species.
Medical subject headings
- Apoptosis
- Cytoprotection
- DNA-Binding Proteins
- Interleukin-6
- Liver
- Trans-Activators
- fas Receptor