Selectin and selectin ligand binding: a bittersweet attraction.
other · Level V
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- Record sourced from PubMed, PMID 14523033.
- Also identified by PMC identifier 198533.
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Abstract
Inhibition of leukocyte migration into target organs has long been an attractive, though challenging, basis for anti-inflammatory strategies. However, to date, the manipulation of leukocyte rolling along blood vessels has not yielded successful new therapies. An important study may now open new avenues in this exciting field of anti-inflammatory therapies by introducing a putative inhibitor of poly-N-acetyllactosamine biosynthesis that affects selectin ligand activity and shows efficacy in a rodent skin inflammation model.
Medical subject headings
- Acetylglucosamine
- Dermatitis, Contact
- E-Selectin
- Membrane Glycoproteins
- Skin
- T-Lymphocytes