Finding NEMO: genetic disorders of NF-[kappa]B activation.
Level V
Where this comes from
- Record sourced from PubMed, PMID 14523034.
- Also identified by PMC identifier 200971.
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Abstract
The pathways between a receptor and transcriptional activation mediated by NF-kappaB are complex. The study of human gene mutations that result in dysregulation of these pathways has provided insight into the functions of individual components of the pathway, their interrelations, and the significance of these systems to the organism.
Medical subject headings
- Ectodermal Dysplasia
- I-kappa B Proteins
- Immunologic Deficiency Syndromes
- Mutation
- NF-kappa B
- Protein Serine-Threonine Kinases
- T-Lymphocytes