Neuroscience. Stout guards of the central nervous system.
other · Level V
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- Record sourced from PubMed, PMID 14526067.
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Abstract
Endocannabinoids have paradoxical effects on the mammalian nervous system: Sometimes they block neuronal excitability and other times they augment it. In their Perspective, Mechoulam and Lichtman discuss new work (Marsicano et al.) showing that activation of the cannabinoid receptor CB1 by the endocannabinoid anandamide protects against excitotoxic damage in a mouse model of kainic acid-induced epilepsy.
Medical subject headings
- Arachidonic Acids
- Brain
- Cannabinoids
- Epilepsy
- Neuroprotective Agents
- Receptors, Drug