Additional antitumor ecteinascidins from a Caribbean tunicate: crystal structures and activities in vivo.
basic_science · Level V
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- Record sourced from PubMed, PMID 1454834.
- Also identified by PMC identifier 50570.
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Abstract
Ecteinascidins (Ets), isolated from the Caribbean tunicate Ecteinascidia turbinata, protect mice in vivo against P388 lymphoma, B16 melanoma, M5076 ovarian sarcoma, Lewis lung carcinoma, and the LX-1 human lung and MX-1 human mammary carcinoma xenografts. Crystal structures of two tris(tetrahydroisoquinoline) Ets were investigated with single crystals of the 21-O-methyl-N12-formyl derivative of Et 729 and the natural N12-oxide of Et 743. Representatives of an additional class of Ets, Et 722 and Et 736, isolated from the same organism, were assigned tetrahydro-beta-carboline-substituted bis(tetrahydroisoquinoline) structures by NMR and fast atom bombardment MS spectra.
Medical subject headings
- Antineoplastic Agents
- Isoquinolines
- Urochordata