Borna disease virus, a negative-strand RNA virus, transcribes in the nucleus of infected cells.
basic_science · Level V
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- Record sourced from PubMed, PMID 1454837.
- Also identified by PMC identifier 50576.
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Abstract
Borna disease virus, an unclassified infectious agent, causes immune-mediated neurologic disease in a wide variety of animal hosts and may be involved in pathogenesis of selected neuropsychiatric diseases in man. Initial reports suggested that Borna disease virus is a single-stranded RNA virus. We describe here a method for isolation of viral particles that has allowed definitive identification of the genome as containing a negative-polarity RNA. Further, we show that the viral mRNAs are transcribed in the nucleus.
Medical subject headings
- Borna disease virus
- RNA Viruses
- RNA, Viral
- Virus Diseases