GCHap: fast MLEs for haplotype frequencies by gene counting.
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- Record sourced from PubMed, PMID 14555636.
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Abstract
GCHap quickly finds maximum likelihood estimates (MLEs) of frequencies of haplotypes given genotype information on a random sample of individuals. It uses the gene counting method but by excluding haplotypes with zero MLE at an early stage, this implementation uses many orders of magnitude less space and time than naive implementations. A second program, ApproxGCHap, is provided to give alternate estimates for data sets with large numbers of loci or large amounts of missing genotypes. The Java classes and Javadocs pages for GCHap can be obtained from bioinformatics.med.utah.edu/~alun
Medical subject headings
- Algorithms
- Gene Expression Profiling
- Gene Frequency
- Genetic Linkage
- Haplotypes
- Hypermedia
- Sequence Analysis, DNA
- Software