Receptor "cross talk" in innate immunity.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 14561697.
- Also identified by PMC identifier 213495.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Toll-like receptors (TLRs) recognize microbial molecular signatures and can initiate innate immune responses against invading pathogens. A new study (see the related article beginning on page 1234) reports how TLR2 expression by endothelia is locally upregulated by the action of activated polymorphonuclear neutrophils via an unprecedented mechanism involving cell-cell interaction and NAD(P)H oxidase. The report reveals yet another way in which the primordial innate immune system is remarkably complex.
Medical subject headings
- Membrane Glycoproteins
- NADPH Oxidases
- Neutrophils
- Receptors, Cell Surface