A novel role for uroguanylin in the regulation of sodium balance.
editorial · Level V
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- Record sourced from PubMed, PMID 14561698.
- Also identified by PMC identifier 213496.
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Abstract
Uroguanylin is a peptide hormone that regulates sodium excretion by the kidney when excess NaCl is consumed. A new study demonstrates that mice deficient in uroguanylin have blunted urinary sodium excretion responses to oral sodium loads in addition to elevated blood pressure (see related article beginning on page 1244). A physiological role for uroguanylin is discussed, linking the intestine and kidney in an endocrine axis for the maintenance of sodium balance.
Medical subject headings
- Peptides
- Sodium