Medicine. PPARs as therapeutic targets: reverse cardiology?
editorial · Level V
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Abstract
Formation of the atherosclerotic lesions that lead to myocardial infarction is determined in part by inflammatory responses such as the production of lipid-laden macrophages. In his Perspective, Plutzky highlights the parts played by PPAR nuclear receptors, especially PPAR-delta (Lee et al.), in the modulation of inflammatory responses and hence atherosclerosis.
Medical subject headings
- Arteriosclerosis
- Inflammation
- Macrophages
- Receptors, Cytoplasmic and Nuclear
- Transcription Factors