Critical roles for Rac1 and Rac2 GTPases in B cell development and signaling.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 14564011.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The Rac1 guanosine triphosphatase (GTPase) has been implicated in multiple cellular functions, including actin dynamics, proliferation, apoptosis, adhesion, and migration resulting from signaling by multiple receptors, including the B cell antigen receptor (BCR). We used conditional gene targeting to generate mice with specific Rac1 deficiency in the B cell lineage. In the absence of both Rac1 and the highly related Rac2, B cell development was almost completely blocked. Both GTPases were required to transduce BCR signals leading to proliferation, survival and up-regulation of BAFF-R, a receptor for BAFF, a key survival molecule required for B cell development and maintenance.
Medical subject headings
- B-Lymphocytes
- Receptors, Antigen, B-Cell
- Signal Transduction
- rac GTP-Binding Proteins
- rac1 GTP-Binding Protein