R2D2 leads the silencing trigger to mRNA's death star.
basic_science · Level V
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Abstract
During RNA interference (RNAi), Dicer generates short interfering RNAs (siRNAs), which then guide target mRNA cleavage by the RISC complex. Now, Liu et al. identify R2D2, a Dicer-associated protein that is important for siRNA incorporation into RISC, thus linking the initiation and execution phases of RNAi.
Medical subject headings
- Drosophila Proteins
- RNA Interference
- RNA-Binding Proteins