Targeting survival: integration site selection by retroviruses and LTR-retrotransposons.
review · Level V
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Abstract
Replication of retroviruses and retrotransposons depends on selecting a favorable chromosomal site for integration of their genomic DNA. Different retroelements meet this challenge by targeting distinctive chromosomal regions. Despite these differences, recent data hints at a common targeting mechanism-tethering of integration complexes to proteins bound at favorable sites.
Medical subject headings
- DNA Transposable Elements
- Retroviridae
- Virus Integration