The role of Notch in tumorigenesis: oncogene or tumour suppressor?
review · Level V
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- Record sourced from PubMed, PMID 14570040.
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Abstract
Notch signalling participates in the development of multicellular organisms by maintaining the self-renewal potential of some tissues and inducing the differentiation of others. Involvement of Notch in cancer was first highlighted in human T-cell leukaemia, fuelling the notion that aberrant Notch signalling promotes tumorigenesis. However, there is mounting evidence that Notch signalling is not exclusively oncogenic. It can instead function as a tumour suppressor.
Medical subject headings
- Genes, Tumor Suppressor
- Membrane Proteins
- Neoplasms
- Oncogenes
- Trans-Activators