Cardiac failure after initiation of insulin treatment in diabetic patients with beta-thalassemia major.

Konrad, Daniel; Daneman, Denis; Kirby, Melanie; Wherrett, Diane · J Pediatr · 2003

case_report · Level V

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Abstract

Diabetes mellitus is a complication of beta-thalassemia major. Two patients are described who developed severe cardiac failure after initiation or intensification of insulin treatment. We hypothesize that insulin-induced fluid retention combined with reduced cardiac reserve was responsible for the cardiac failure. Careful initiation of insulin treatment in these patients is important.

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