Rapid fibroblast adhesion to 27nm high polymer demixed nano-topography.
basic_science · Level V
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- Record sourced from PubMed, PMID 14580911.
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Abstract
It is well known that many cell types react strongly to micro-topography. It is rapidly becoming clear than cells will also react to nano-topography. Polymer demixing is a rapid and low-cost chemical method of producing nano-topography. This manuscript investigates human fibroblast response to 27nm high nano-islands produced by polymer demixing. Cell spreading, cytoskeleton, focal adhesion and Rac localisation were studied. The results showed that an initial rapid adhesion and cytoskeletal formation on the islands at 4 days of culture gave way to poorly formed contacts and vimentin cytoskeleton at 30 days of culture.
Medical subject headings
- Biocompatible Materials
- Culture Techniques
- Fibroblasts
- Nanotechnology
- Polystyrenes
- Styrenes
- Tissue Engineering