TIMP-3 mRNA is not overexpressed in Sorsby fundus dystrophy.
case_report · Level V
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Abstract
To assess the expression of MMP (matrix metalloproteinase)-2 and -9 and TIMP (tissue inhibitors of metalloproteinases)-1, -2, and -3 in Sorsby fundus dystrophy. Cliniciopathological report. A donor eye with a confirmed S181C mutation in the TIMP-3 gene and an age-matched normal donor eye were studied using in situ hybridization technique with MMP -2 and -9 and TIMP -1, -2, and -3 probes. There is a reduction of mRNA expression of MMP-2 and TIMP-3 in the Sorsby retinal pigment epithelium cells. Increased expression of TIMP-3 mRNA does not cause accumulation of TIMP-3 in the Bruch membrane of Sorsby fundus dystrophy nor is it likely to cause age-related macular degeneration.
Medical subject headings
- Fundus Oculi
- Pigment Epithelium of Eye
- RNA, Messenger
- Retinal Degeneration
- Tissue Inhibitor of Metalloproteinases