The TRAIL to arthritis.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 14597758.
- Also identified by PMC identifier 228491.
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Abstract
Antigen-specific lymphocytes are involved in synovial proliferation within inflamed joints. Activated lymphocytes and synoviocytes from patients with rheumatoid arthritis express receptors that can bind TNF-related apoptosis-inducing ligand (TRAIL). A new study demonstrates that DCs pulsed with collagen and transduced with an adenovirus-based vector able to express TRAIL limit the incidence of arthritis in a model of collagen-induced arthritis and joint inflammation. These results suggest that gene-modified cell therapy represents a therapeutic option for systemic rheumatic diseases.
Medical subject headings
- Arthritis, Rheumatoid
- Cell- and Tissue-Based Therapy
- Collagen
- Dendritic Cells
- Genetic Therapy
- Membrane Glycoproteins
- Tumor Necrosis Factor-alpha