Yeast life-span extension by calorie restriction is independent of NAD fluctuation.
basic_science · Level V
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- Record sourced from PubMed, PMID 14605207.
- Also identified by DOI 10.1126/science.1088697 and PMC identifier 4998187.
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Abstract
Calorie restriction (CR) slows aging in numerous species. In the yeast Saccharomyces cerevisiae, this effect requires Sir2, a conserved NAD+-dependent deacetylase. We report that CR reduces nuclear NAD+ levels in vivo. Moreover, the activity of Sir2 and its human homologue SIRT1 are not affected by physiological alterations in the NAD+:NADH ratio. These data implicate alternate mechanisms of Sir2 regulation by CR.
Medical subject headings
- Bacterial Proteins
- Histone Deacetylases
- NAD
- Saccharomyces cerevisiae
- Silent Information Regulator Proteins, Saccharomyces cerevisiae
- Sirtuins