Distinct cytokine profile in SIDS brain: a common denominator in a multifactorial syndrome?
basic_science · Level V
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Abstract
Cytokines modify neuronal function. Dysfunction in vital centers is reported in sudden infant death syndrome (SIDS). The authors detected high neuronal interleukin (IL)-1beta immunoreactivity in the arcuate and dorsal vagal nuclei in SIDS. This IL-1 overexpression might contribute to molecular interactions in brainstem neurovegetative centers, causing disturbed homeostatic control of cardiorespiratory and arousal responses, possibly leading to SIDS.
Medical subject headings
- Brain
- Brain Chemistry
- Cytokines
- Interleukin-1
- Sudden Infant Death