Alternating gene expression in fibroblasts adhering to multilayers of chitosan and dextran sulfate.
basic_science · Level V
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Abstract
The alternating compatibility of fibroblast cells adhering to multilayers of chitosan and dextran sulfate (Dex) on a substrate was analyzed at the gene expression level. A greater number of round-shaped cells adhered to the films with an outermost surface composed of Dex, although the total number of adherent cells was independent of the film surface. Greater expression of heat-shock protein 70B mRNA was demonstrated in cells adhering to films with the Dex surface. It was found that analysis of gene expression was a powerful tool for evaluating the bioactivity of multilayers.
Medical subject headings
- Biocompatible Materials
- Chitin
- Dextran Sulfate
- Fibroblasts
- Gene Expression Profiling