Oral administration of beta-lactamase preserves colonization resistance of piperacillin-treated mice.
basic_science · Level V
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Abstract
We hypothesized that orally administered, recombinant class A beta-lactamase would inactivate the portion of parenteral piperacillin excreted into the intestinal tract, preserving colonization resistance of mice against nosocomial pathogens. Subcutaneous piperacillin or piperacillin plus oral beta-lactamase were administered 24 and 12 h before orogastric inoculation of piperacillin-resistant pathogens. Oral administration of beta-lactamase reduced piperacillin-associated alteration of the indigenous microflora and prevented overgrowth of pathogens.
Medical subject headings
- Anti-Bacterial Agents
- Piperacillin
- beta-Lactamases