Metformin lactic acidosis, acute renal failure and rofecoxib.
case_report · Level V
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- Record sourced from PubMed, PMID 14633764.
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Abstract
A patient with acute renal failure associated with lactic acidosis as a result of concurrent treatment with metformin is described. Rofecoxib may have been a precipitating factor. The risk of renal failure with the use of traditional NSAIDs is well known. However, what is less well appreciated is the role that the COX 2 inhibitors may play in the development of renal failure which, when it occurs in a patient on metformin, can lead to a potentially disastrous outcome.
Medical subject headings
- Acidosis, Lactic
- Acute Kidney Injury
- Cyclooxygenase Inhibitors
- Hypoglycemic Agents
- Lactones
- Metformin