MoMLV reverse transcriptase regulates its own expression.
basic_science · Level V
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Abstract
A precise ratio of Gag:Gag-Pol expression is required for assembly of infectious retroviral virions. In this issue of Cell, Orlova et al. show that MoMLV reverse transcriptase binds the translation release factor eRF1, and that this interaction promotes translation readthrough to make Gag-Pol.
Medical subject headings
- Fusion Proteins, gag-pol
- Moloney murine leukemia virus
- Peptide Termination Factors
- Protein Biosynthesis
- RNA-Directed DNA Polymerase
- Virus Replication