HtrA2/Omi, a sheep in wolf's clothing.
basic_science · Level V
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- Record sourced from PubMed, PMID 14636553.
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Abstract
Mammalian mitochondrial HtrA2/Omi was originally described as an apoptosis inducer, but rather than having extra cells, mice with mutant HtrA2/Omi suffer from a neurodegenerative disease due to progressive mitochondrial damage. This suggests that instead of promoting cell death by antagonizing inhibitor of apoptosis (IAP) proteins, the primary function of HtrA2/Omi is to handle misfolded proteins in the mitochondria.
Medical subject headings
- Mitochondria
- Neurodegenerative Diseases
- Serine Endopeptidases