Screening for DJ-1 mutations in early onset autosomal recessive parkinsonism.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 14638971.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The DJ-1 gene was identified as responsible for early onset autosomal recessive parkinsonism in two families (PARK7). In this study, after excluding mutations in the parkin gene, the authors screened a large series of early onset autosomal recessive parkinsonism families and consanguineous isolated patients of diverse geographic origins for DJ-1 mutations. No mutations were found. This indicates that PARK7 is not a common locus for early onset autosomal recessive parkinsonism, and that one or more new loci remains to be identified.
Medical subject headings
- Mutation
- Oncogene Proteins
- Parkinsonian Disorders