A fibrin based model for rheumatoid synovitis.
basic_science · Level V
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- Record sourced from PubMed, PMID 14644849.
- Also identified by PMC identifier 1754399.
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Abstract
Intracavitary fibrin clots may initiate pannus formation and the immunopathology of RA. Two critical steps, probably host dependent, may determine the development of RA: an altered regulation of extravascular haemostasis or an aberrant reactivity of synovial fibroblasts to the adhered fibrin clots. Current treatments for RA target events downstream of fibrin deposition, perhaps agents acting at an earlier stage should be tried.
Medical subject headings
- Arthritis, Rheumatoid
- Fibrin
- Synovitis