Wild-type p53 binds to the TATA-binding protein and represses transcription.
basic_science · Level V
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- Record sourced from PubMed, PMID 1465435.
- Also identified by PMC identifier 50691.
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Abstract
p53 activates transcription of genes with a p53 response element, and it can repress genes lacking the element. Here we demonstrate that wild-type but not mutant p53 inhibits transcription in a HeLa nuclear extract from minimal promoters. Wild-type but not mutant p53 binds to human TATA-binding protein (TBP). p53 does not bind to yeast TBP, and it cannot inhibit transcription in a HeLa extract where yeast TBP substitutes for human TBP. These results suggest a model in which p53 binds to TBP and interferes with transcriptional initiation.
Medical subject headings
- DNA-Binding Proteins
- Gene Expression Regulation
- TATA Box
- Transcription Factors
- Transcription, Genetic
- Tumor Suppressor Protein p53