Strength and voluntary activation of the quadriceps femoris muscle at different severities of osteoarthritic knee joint damage.

Abstract

Improvements of quadriceps motor deficits represent a major therapeutical target in knee osteoarthritis (OA). In the present study, we investigated changes in quadriceps function at different stages of osteoarthritic cartilage damage. Measurements of quadriceps voluntary activation (VA) and maximum voluntary contraction (MVC) were performed by a twitch interpolation technique and the total muscular capacity (TMC) was calculated as the ratio of MVC and VA. We assessed 68 patients (56.7+/-9.5 years) with stage II and 154 patients (65.6+/-6.0 years) with stage IV chondropathy. As controls, we used 85 age related healthy subjects (58.1+/-8.7 years). While TMC was significantly lower in stage IV (90.6+/-43.7 Nm) than in stage II chondropathy (109.6+/-51.0) there were no differences in the MVCs between both groups. Quadriceps VA was even higher in stage IV (77.2+/-13.2%) than in stage II chondropathy (70.8+/-16.0%). In the controls, MVC, VA and TMC were significantly higher than in both OA groups. We assume that a decrease of TMC might occur within the course of OA and, in consequence, VA increases to maintain quadriceps MVC.