Sequence similarity between HLA-DR1 and DR4 subtypes associated with rheumatoid arthritis and proteus/serratia membrane haemolysins.
basic_science · Level V
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- Record sourced from PubMed, PMID 1466602.
- Also identified by PMC identifier 1012464.
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Abstract
Rheumatoid arthritis (RA) is found more often in subjects carrying the HLA-DR1 antigen and some subtypes of the HLA-DR4 antigen than in those without these antigens. Analysis of probes specific for HLA-DR4 has shown that amino acids encoding positions 69-74 (EQRRAA) of the beta chain indicates susceptibility to RA. A hexamer sequence of proteus haemolysin spanning residues 32-37 (ESRRAL) has been identified which resembles biochemically, and discriminates by charge, between HLA types associated with RA (DR1, Dw4, Dw14, Dw15), and those not linked with the disease (Dw10, Dw13).
Medical subject headings
- Antigens, Bacterial
- Arthritis, Rheumatoid
- HLA-DR1 Antigen
- HLA-DR4 Antigen
- Hemolysin Proteins
- Proteus