Using credibility intervals instead of hypothesis tests in SAGE analysis.
other · Level V
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Abstract
Statistical methods usually used to perform Serial Analysis of Gene Expression (SAGE) analysis are based on hypothesis testing. They answer the biologist's question: 'what are the genes with differential expression greater than r with P-value smaller than P?'. Another useful and not yet explored question is: 'what is the uncertainty in differential expression ratio of a gene?'. We have used Bayesian model for SAGE differential gene expression ratios as a more informative alternative to hypothesis tests since it provides credibility intervals. The model is implemented in R statistical language script and is available under GNU/GLP copyleft at supplemental web site. http://www.ime.usp.br/~rvencio/SAGEci/
Medical subject headings
- Algorithms
- Gene Expression Profiling
- Models, Genetic
- Models, Statistical
- Sequence Analysis, DNA