Is the "K-type" caffeine-halothane responder susceptible to malignant hyperthermia?
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Abstract
The "K-type" designation is used to describe a patient being investigated for malignant hyperthermia (MH) when concurrent administration of caffeine and halothane induces muscle contracture (rigidity, spasm) in vitro, but when halothane and caffeine given separately produce a normal response. It is accepted in some centres that K-type individuals are susceptible to malignant hyperthermia (MHS). In this paper, the K-type is shown not to correlate with the MH susceptible (MHS) status as accepted by the European MH group.
Medical subject headings
- Caffeine
- Halothane
- Malignant Hyperthermia