Coupled folding during translation initiation.
basic_science · Level V
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Abstract
The structure of the eukaryotic initiation factor eIF4E bound to a cognate domain of eIF4G and m(7)GDP in this issue of Cell shows that these factors undergo coupled folding to form a stable complex with high cap binding activity that promotes efficient ribosomal attachment to mRNA during translation initiation.
Medical subject headings
- Eukaryotic Initiation Factor-4E
- Eukaryotic Initiation Factor-4G
- Guanosine Diphosphate
- Protein Biosynthesis
- Protein Folding
- RNA, Messenger