The secret life of ACE2 as a receptor for the SARS virus.
review · Level V
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- Record sourced from PubMed, PMID 14675530.
- Also identified by PMC identifier 7133233.
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Abstract
The membrane-associated carboxypeptidase angiotensin-converting enzyme 2 (ACE2) is an essential regulator of heart function. Now, Li at al. identify and characterize an unexpected second function of ACE2 as a partner of the SARS-CoV spike glycoprotein in mediating virus entry and cell fusion.
Medical subject headings
- Carboxypeptidases
- Receptors, Cell Surface
- Severe acute respiratory syndrome-related coronavirus
- Viral Fusion Proteins