Tumbling down a different pathway to genetic instability.
review · Level V
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- Record sourced from PubMed, PMID 14679175.
- Also identified by PMC identifier 297004.
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Abstract
Ulcerative colitis (UC), a chronic inflammatory condition associated with a predisposition to colon cancer, is frequently characterized by DNA damage in the form of microsatellite instability (MSI). A new report links inflammation in UC with increases in the DNA repair enzymes 3-methyladenine DNA glycosylase and apurinic/apyrimidinic endonuclease, and, paradoxically, with increased MSI. These findings may represent a novel mechanism contributing to MSI in chronic inflammation.
Medical subject headings
- Colitis, Ulcerative
- DNA Damage
- Microsatellite Repeats